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Crystal structure of the SAP97 PDZ2 I342W C378A double mutant (pwPDZ2; Protein Data Bank entry 2x7z).A, ribbon representation of the crystal structure of pwPDZ2. The side chain of Trp342 is shown as all-atom model. B, annealed Fo − Fc omit map of Trp342 shown at the level of 3.5 σ.