Table 2.
Area under the curve of lipid fractions in the postprandial study (mean ± SE).
| ABCA1 R219K | ABCA1 i48168 | ABCA1 i27943 | |
|---|---|---|---|
| Total TG | GG 79.5 ± 5.0 | CC 56.6±7.3* | GG 56.8 ± 7.8‡ |
| GA/AA 70.9 ± 5.9 | CT 76.5±4.7 | GA 76.4 ± 4.7 | |
| TT 89.6±9.0 | AA 87.1 ± 9.1 | ||
| CHOL | GG 80.9 ± 1.7 | CC 79.9±2.7 | GG 78.5 ± 2.8 |
| GA/AA 80.8 ± 2.1 | CT 81.1±1.7 | GA 81.9 ± 1.7 | |
| TT 79.9±2.7 | AA 79.0 ± 3.3 | ||
| large-TRL TG | GG 33.4 ± 2.5 | CC 20.9±3.5* | GG 21.6 ± 3.7‡ |
| GA/AA 28.7 ± 3.0 | CT 31.8±2.3 | GA 31.3 ± 2.3 | |
| TT 38.2±4.4 | AA 37.3 ± 4.5 | ||
| small-TRL TG | GG 23.7 ± 2.0 | CC 20.3±3.1 | GG 20.1 ± 3.2 |
| GA/AA 23.4 ± 2.4 | CT 23.9±2.0 | GA 24.1 ± 2.0 | |
| TT 24.9±3.9 | AA 24.2 ± 3.9 | ||
| large-TRL CHOL | GG 4.7 ± 0.3 | CC 4.7±0.4 | GG 4.8 ± 0.4 |
| GA/AA 4.8 ± 0.3 | CT 4.7±0.2 | GA 4.7 ± 0.3 | |
| TT 4.6±0.5 | AA 4.7 ± 0.5 | ||
| small-TRL CHOL | GG 6.3 ± 0.4 | CC 5.5±0.7 | GG 5.7 ± 0.7 |
| GA/AA 6.0 ± 0.5 | CT 6.1±0.5 | GA 5.9 ± 0.4 | |
| TT 6.5±0.9 | AA 6.9 ± 0.9 | ||
| APOA1 | GG 54.0 ± 1.3 | CC 60.1±1.9† | GG 59.1 ± 2.1§ |
| GA/AA 56.6 ± 1.5 | CT 53.6±1.2 | GA 54.2 ± 1.2 | |
| TT 55.9±2.4 | AA 55.9 ± 2.4 | ||
| APOB | GG 35.1 ± 1.1 | CC 32.6±1.7 | GG 31.8 ± 1.7§ |
| GA/AA 35.5 ± 1.3 | CT 36.2±1.1 | GA 36.5 ± 1.0 | |
| TT 34.8±2.1 | AA 34.2 ± 2.0 | ||
| HDL | GG 23.7 ± 0.8 | CC 26.0±1.2 | GG 25.3 ± 1.3 |
| GA/AA 24.2 ± 0.9 | CT 23.5±0.7 | GA 23.9 ± 0.8 | |
| TT 23.8±1.4 | AA 23.8 ± 1.5 | ||
Univariate ANOVA using BMI and age as covariates. TG: Triacylglycerols; Chol: Cholesterol; TRL: TG Rich Lipoproteins. All values are expressed as (min*mg/dl)/103. Superscripts in cells are as follows:
*
=p<0.05 ABCA1 i48168 CC vs CT and CC vs TT;
†
=p<0.05 ABCA1 i48168 CC vs CT;
‡
=p<0.05 ABCA1 i27943 GG vs GA and GG vs AA;
§
=p<0.05 ABCA1 i27943 GG vs GA.