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. Author manuscript; available in PMC: 2011 May 27.
Published in final edited form as: J Phys Chem B. 2010 May 27;114(20):7022–7028. doi: 10.1021/jp911527y

Figure 1.

Figure 1

H-bonding interactions of amide group of Asn/Gln in X-ray crystal structures of PDEs. (A) The amide oxygen and nitrogen atoms of Asn641 have sterically unfavorable interactions with the main chain oxygen of Arg664 which has two H-bonds with backbone nitrogen atoms of Gly667 and Leu668 in 2OUQ (PDE10, resolution 1.9Å).19 (B) The amide oxygen and nitrogen atoms of Gln326 have sterically unfavorable interactions with the main chain oxygen of Leu420 and the ammonium ion of the side chain of Lys359 in PDB code 1ZXL (PDE7, resolution 1.67Å).30