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. Author manuscript; available in PMC: 2011 Apr 2.
Published in final edited form as: J Control Release. 2010 Jan 6;143(1):38–44. doi: 10.1016/j.jconrel.2009.12.021

Table 1.

Effects of Dox Loading Method on Particle Size and PDI

Unloaded UCA H-Dox-UCA I-Dox-UCA S-Dox-UCA
Particle Size
(nm)		 1692 +/− 779 1734 +/− 1403 1865 +/− 1074 2206 +/− 2039
PDI 0.212 +/−0.051 0.254 +/−0.104 0.309 +/− 0.102 * 0.412 +/−0.108

No statistically significant changes in particle size were detected among loading groups with peak particle sizes ranging from 1.7 µm to 2.2 µm. Both the H-Dox-UCA and I-Dox-UCA groups showed a PDI similar to that of the unloaded agent, indicating no changes in the size distribution had taken place. However, the S-Dox-UCA did show a significantly higher PDI

(*p=0.0441 relative to the unloaded control).