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LV passive stiffness [change in pressure over volume (dP/dV)] before (intact VP) and after VP disruption. VP disruption significantly reduced LV stiffness at lower volumes, as indicated by the asterisks (0–20 ml, P < 0.05), but not in higher volumes (20–70 ml, P < 0.05). This suggests that the mechanical effect of VP disruption is primarily due to disruption of the elastin elements of the VP and that other elements remain viable at the higher ranges measured in this study.
