Table 3.

Consolidated results from mouse and human experiments demonstrate translational validity of event-related potentials technique

	Mouse P20	Human P50
Stimulus	S1 > S2	S1 > S2
Nicotine/smoking	↑S1	↑S1
Varenicline	↑(S1, S2)	↑(S1, S2)a

Note. In both species, habituation of the second stimulus relative to the first can be observed. Nicotine in mice selectively increases P20 response to S1, just as smoking in human selectively increases P50 response to S1. Last, varenicline increases overall ERP amplitude in both species.

^aNote that some subjects did not show differences between placebo and varenicline due to a possible carryover effect.