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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Dev Biol. 2010 Feb 6;340(2):459–467. doi: 10.1016/j.ydbio.2010.01.039

Fig. 1. Loss of Dicer in the NC lineage results in severe cranial malformations.

Fig. 1

Dicer was deleted in the NC lineage using the Wnt1-Cre deleter line and newborn pups were analyzed for gross phenotypic changes. (A) Dicerfx/+ newborn pups are phenotypically normal. (B) Dicerfx/fx; Wnt1-Cre pups show severe growth retardation of the head with the most pronounced defects in the anterior craniofacial region.