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. Author manuscript; available in PMC: 2010 Dec 18.
Published in final edited form as: Immunity. 2009 Dec 10;31(6):909–920. doi: 10.1016/j.immuni.2009.09.023

Figure 1. Vβ Use by Retrogenic Treg and Tconv Cells.

Figure 1

CD4+ T lymphocytes from retrogenic mice, preimmune or 22–28 days after EAE induction, were flow cytometrically analyzed with a panel of TCR Vβ-specific antibodies. Comparisons were made between Tconv (A) and Treg (B) cells from unimmunized and immunized splenocytes and CNS T cells from mice with EAE. A significant increase in Vβ8.1 or 8.2 splenocytes was seen among Tconv cells (p = 0.018), and a decrease in Vβ8.3 TCR among Treg cells (p = 0.048) when comparing pre- or immune splenic and CNS-infiltrating populations. Data show mean + 1 SEM. *p < 0.05 among group by Hochberg-adjusted 1-way ANOVA.