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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Blood Cells Mol Dis. 2010 Apr 14;45(1):23–28. doi: 10.1016/j.bcmd.2010.03.007

Figure 1.

Figure 1

The 5′ region of RPS19 with known UTR variants and degree of conservation.

(A) Exon 1 and the 5′UTR variants retrieved from the NCBI database (http://www.ncbi.nih.gov/) using the UCSC genome browser (http://www.genome.ucsc.edu/). The most abundant 5′UTR variant (boxed) spans 35 nucleotides and contains a 5′TOP sequence [20]. The sequence conservation between mammals is indicated (for details, see Martinez Barrio et al [5]). No common variants have been reported in the human polymorphism database (dbSNP, http://www.ncbi.nlm.nih.gov/SNP/, build 130). (B) Alignment of the human 35 nt 5′UTR region containing the TOP sequence with orthologous sequences from 24 additional mammalian species. The 5′UTR TOP sequence (D28389) is highly conserved.