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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Hippocampus. 2010 Jun;20(6):768–786. doi: 10.1002/hipo.20678

Figure 4.

Figure 4

Effects of Chronic Stress and 17β-Estradiol Implants on the Water Maze. (A) A significant main effect of hormone treatment was found for distance to locate the platform, with SE and NE covering significantly less distance before finding the platform compared to SC and NC. Note: the means were shifted on the x-axis in to facilitate visualization of the data. Each block represents the average of two training trials. *P<0.05 for SE and NE vs. NC, SC. (B) A second analysis was performed on the first two blocks and revealed that SE covered significantly less distance to locate the platform compared to NE and SX. ** P≤0.01 for SE vs. SX or NE. (C) The percentage of time spent searching during the probe trial. Rats spent more time searching the quadrant that previously contained the platform (Target) compared to the opposite quadrant (Opposite, *P=0.01). (D) Latency to find the visible platform. No significant differences were observed across groups and all rats quickly located the visible platform. Non-stress control-blank (NX), non-stress control-cholesterol (NC), non-stress control-estradiol (NE), stress-blank (SX), stress-cholesterol (SC), stress-estradiol (SE).