Table 1.
Stress History: Hormone: Group: |
Non-Stress Control + Blank (NX) | Non-Stress Control + Cholesterol (NC) | Non-Stress Control + 17β-Estradiol (NE) | Stress + Blank (SX) | Stress + Cholesterol (SC) | Stress + 17β-Estradiol (SE) |
---|---|---|---|---|---|---|
Behavioral Measures from the Y-Maze | ||||||
%Novel Arm Entries | 46.9 ± 4.2* | 42.7 ± 2.5 | 52.0 ± 2.4* | 41.2 ± 6.4 | 51.4 ± 5.3* | 48.7 ± 2.4* |
%Other Arm Entries | 31.0 ± 3.0 | 31.0 ± 3.0 | 28.3 ± 2.2 | 37.7 ± 4.2 | 27.8 ± 4.6 | 26.3 ± 2.2 |
Difference Scores | 15.9 ± 5.9 | 9.8 ± 5.0 | 23.7 ± 3.9 | 3.5 ± 10.2 | 23.6 ± 9.0 | 22.4 ± 4.3 |
Total Entries | 3.9 ± 0.3a | 5.4 ± 0.3a | 5.3 ± 0.4b | 4.5 ± 0.5a | 4.3 ± 0.4a | 5.6 ± 0.3b |
Physiological Measures | ||||||
Serum Estradiol (pg/ml) | 9.5 ± 2.3a | 20.0 ± 1.0b | 53.2 ± 3.0c | 12.0 ± 2.5a | 21.9 ± 1.4b | 58.1 ± 4.0c |
Body Wt Day 0 (g) | 240.2 ± 4.6a | 240.8 ± 3.9a | 240.0 ± 2.2a | 239.5 ± 2.6a | 237.9 ± 2.8a | 240.2 ± 4.1a |
Body Wt Day 21 (g) | 329.6 ± 5.8b | 329.0 ± 5.3b | 254.6 ± 4.5d | 287.5 ± 3.4c | 290.3 ± 4.0c | 245.4 ± 3.9a |
Indicates preference for the “Novel” arm over the previously explored “Other” arm within a given column. Within a given row for Total Entries or Serum Estradiol Levels, means with different letters indicate values that are statistically different (P<0.05, i.e., compare “a” vs. “b”), whereas means with similar letters represent values that are statistically similar (i.e., compare “a” vs. “a”). For Body Weight, means with different letters indicate values that are statistically different (P<0.05, i.e., compare “a” vs. “b”) across two rows: Day 0 and Day 21.