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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Pharmacol Biochem Behav. 2010 Apr 2;96(1):7–15. doi: 10.1016/j.pbb.2010.03.014

Figure 3. Exploratory behavior of DAT WT and KD mice in a modified BPM environment.

Figure 3

The same DAT WT and KD mice were reassessed in the BPM but with a modified environment in half of the BPM chambers. The BPM was altered by placing sandpaper on the floor, as well as inserting novel objects in four of the holes in the chambers. This novel environment was created to ascertain whether it would reinstate the mania-like phenotype of DAT KD mice observed when first placed in the BPM. The novel environment did elicit a significant increase in transitions in DAT KD, but not WT mice (A). Although the novel environment increased holepoking in DAT KD mice consistent with the increase in transitions, this effect was not significant (B). No effect of environment on holepoking was observed in WT mice either (B). Environment had no effect on rearing (C) in DAT KD or WT mice, with varying effects on spatial d in these mice (D). Data collapsed across sex and presented as mean ± s.e.m., * denotes p < 0.05 when compared to WT control mice, # denotes 0.05 when compared to KD mice in the normal (control) environment.