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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Blood Cells Mol Dis. 2010 Apr 18;45(1):9–19. doi: 10.1016/j.bcmd.2010.03.003

Fig. 6.

Fig. 6

Upregulation of Hif target genes in Phd2 CKO mice. Both young and aging mice were treated with tamoxifen for five consecutive days. Four weeks after the initial dose, the mice were sacrificed. (A) Plasma Epo levels were measured by ELISA. Epo levels in young and aging CKO mice were compared by unpaired Student’s t test and the difference was not found to be statistically significant (p > 0.05). (B to G) RNA was extracted from kidney and liver. The mRNA levels of select genes were determined by Real Time PCR and normalized to that of β-actin. Abbreviations are as follows. Controls: Phd2 f/+ mice; CKO: Phd2 f/−; Rosa26-CreERT2; L: Liver; K: Kidney. For (A) n = 6–9; for (B to G) n = 4. * indicates p < 0.05 and ** indicates p < 0.01 in comparing control and CKO groups.