Table 3.

Results of FBAT analyses for different disease phenotypes. FBAT analysis for transmission of alleles from heterozygous parents to CL, ML and L. braziliensis per se (CL and ML) individuals in families. # families = number of families informative for the FBAT analysis. Data are only shown for the genotype tests where there were sufficient numbers of informative families (>10) contributing to the analysis. S and E(S) represent the observed and expected transmissions. A positive Z score indicates association with disease; a negative Z score indicates the non-associated or protective allele or genotype.

Phenotype	Model	# Families	Allele/Genotype	S	E(S)	Z score	P
CL+ML	Additive	60	G	146	143.53	0.363	0.717
CL+ML	Dominant	29	A	46	51.44	−1.454	0.146
CL+ML	Genotype	29	GG	33	27.56	1.454	0.146
CL+ML	Genotype	60	GA	80	88.41	−1.394	0.163
CL	Additive	58	G	142	139.028	0.443	0.658
CL	Dominant	28	A	45	49.329	−1.175	0.240
CL	Genotype	28	GG	31	26.671	1.175	0.240
CL	Genotype	58	GA	80	85.685	−0.954	0.340
ML	Additive	41	G	41	37.344	0.955	0.339
ML	Dominant	20	A	10	15.77	−2.679	0.007
ML	Genotype	20	GG	13	7.23	2.679	0.007
ML	Genotype	41	GA	15	22.884	−2.46	0.014