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. 2010 May 31;189(5):829–841. doi: 10.1083/jcb.200912105

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© 2010 Pearse et al.

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Figure 4. — Prosaposin is localized to aggresome-like inclusions in ugt1^−/− cells. Prosaposin localization in wild-type (WT) and ugt1^−/− cells was determined by confocal immunofluorescence microscopy. Cells were fixed in 4% paraformaldehyde/PBS and permeabilized in 0.1% Triton X-100. (A) Samples were double labeled with saposin C (SapC) antisera and PDI (ER), GM130 (Golgi), or vimentin (aggresome) antisera. The white boxed regions denote the area magnified in the panels to the right. (B) Samples labeled with full-length prosaposin (Psap) antisera were compared with DIC images. Bars, 10 µm.