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. 2010 May 31;189(5):795–811. doi: 10.1083/jcb.200910043

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© 2010 Chadrin et al.

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Figure 3. — S. cerevisiae Pom33 and Per33 and human TMEM33 are evolutionarily conserved NE/ER-associated proteins. (A) Phylogenic tree of S. cerevisiae Pom33 and Per33 homologues. The tree, based on ClustalW alignment of sequences identified by BLAST searches using ScPom33, ScPer33, and HsTMEM33 (highlighted in bold), was constructed with the Jalview software (www.jalview.org; Waterhouse et al., 2009) based on the percentage of identity between the proteins. (B) ClustalW alignment of ScPom33, ScPer33, and HsTMEM33. Identical residues are colored in black, and similar residues are colored in gray. Asterisks in the consensus line denote residues that are identical in all three proteins sequences, and periods indicate residues that are either identical or similar in at least two out of the three sequences. Approximate positions of the hydrophobic stretches are shown on top of the alignment (black line, see also Fig. S1 C).