Table 3.
Correlation of variables by exposure type associated with gene-specific promoter methylation
Variables | APC | CCND2 | GSTP1 | MGMT | RARβ2 | P16 |
---|---|---|---|---|---|---|
P (χ2)* | P (χ2) | P (χ2) | P (χ2) | P (χ2) | P (χ2) | |
Age | 0.544 | 0.822 | 0.181 | 0.921 | 0.715 | 0.616 |
Nonsmoking | 0.722 | 0.053 | 0.665 | 0.889 | 0.306 | 0.921 |
Income (>$50,000) | 0.187 | 0.011 | 0.567 | 0.06 | 0.068 | 0.507 |
Family cancer history | 0.203 | 0.884 | 0.054 | 0.454 | 0.673 | 0.846 |
Diet and nutrition (high fat) | 0.819 | 0.998 | 0.249 | 0.645 | 0.007 | 0.814 |
CO (<6 ppm) | 0.621 | 0.542 | 0.042 | 0.553 | 0.529 | 0.132 |
Environmental tobacco smoke | 0.315 | 0.353 | 0.368 | 0.043 | 0.25 | 0.007 |
Nonalcohol | 0.125 | 0.016 | 0.43 | 0.321 | 0.088 | 0.367 |
Diabetes | 0.041 | 0.814 | 0.685 | 0.715 | 0.034 | 0.639 |
NOTE: Referent group for each variable: age 1 (40–49) and 2 (50 and 90); current smokers; $0 to $49,999; no cancer in family; low fat; ≥6 ppm; no environmental tobacco smoke exposure; current alcohol; no diabetes.
P ≤ 0.05 was considered statistically significant.