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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Magn Reson Imaging. 2009 Aug;30(2):366–373. doi: 10.1002/jmri.21840

Figure 1.

Figure 1

Two adjacent VX2 rabbit liver tumors (arrows) with central tumor necrotic core and viable tumor periphery. DW-PROPELLER images (a–c) were acquired with needle (arrowheads) positioned to target the viable region of the left-most tumor (diameter = 1.6 cm). The corresponding ADC map reconstructed from baseline DW images demonstrated decreased water mobility at the position of needle placement (d). Contrast-enhanced T1W images at the arterial phase demonstrated perfusion of the tumor periphery (e). Overview H&E pathology image (×25 magnification) (f) of the left-most tumor (yellow contour line at tumor border) shows central necrotic core with viable tumor periphery. Magnified image (g) from inset within ×25 overview image (white dashed-box) shows the location of the injected beads (blue arrowheads) that served as our ex vivo reference for needle tip position. Tumor tissues within the region of bead deposition (×100 magnification image h from inset position within g) were classified as 95% viable at histopathology. Note: Signal void within the center of the right tumor in DW images was due to percutaneous injection of an iron-oxide agent during a previous imaging procedure.