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Intraneuronal Aβ accumulation and impaired LTP in APP/PS1KI mice. Schematic drawing of the hippocampus (A). At 6 months of age deficits in synaptic transmission in the form of altered LTP are detected in APP/PS1KI mice (B–D). Intraneuronal accumulation of Aβ peptides occurs already at 2 months of age in the CA1 region of the hippocampus (E) and precedes neuron loss which becomes evident at 6 months of age (F,G).
