Table 1.
Overview of transgenic AD mouse models in which intraneuronal Aβ accumulation has been reported. In addition, information on extracellular plaque onset, neuron loss and synaptic pathology are given (n.a., not analyzed).
| Transgenic mouse model | Mutation APP | Mutation PS1 | Promoter | Plaque onset | Neuron loss | Synaptic alterations | Reference |
|---|---|---|---|---|---|---|---|
| APP695SDLx/PS1M146L | Swedish, Dutch, London | M146L | PDGF (APP), HMG-CoA (PS1) | 8m | No | n.a. | Wirths et al. (2001) |
| APP751SLx/PS1M146L | Swedish, London | M146L | Thy1 (APP), HMG-CoA (PS1) | 3m | Yes (17m) | Yes | Rutten et al. (2005), Wirths et al. (2002) |
| Tg2576 | Swedish | – | Hamster prion protein | 12m | No | Yes | Dong et al. (2007), Takahashi et al. (2002) |
| 3xTg-AD | Swedish | M146V | Thy1 (APP, Tau), PS1 knock-in | 6m | n.a. | Yes | Billings et al. (2005), Oddo et al. (2003) |
| APP751SL/PS1KI | Swedish, London | M233T, L235P | Thy1 (APP), PS1 knock-in | 2m | Yes (6m) | Yes | Bayer and Wirths (2008), Breyhan et al. (2009) |
| arcAβ | Swedish, Arctic | – | Mouse prion protein | 7m | n.a. | Yes | Knobloch et al. (2007a) |
| 5XFAD | Swedish, Florida, London | M146L, L286V | Thy1 (APP, PS1) | 2m | Yes | Yes | Oakley et al. (2006) |