. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: Am J Physiol Renal Physiol. 2008 Apr 2;294(6):F1323–F1335. doi: 10.1152/ajprenal.00401.2007

Table 1.

Serum lipids, heart/body weight ratio, and histopathologic manifestations of renal injury.

	SR+HSD (n=10)	SS+HSD (n=10)	SS+HSD+CO (n=10)	SS+HSD+HYD (n=6)	SS+HSD+FO (n=10)
Cholesterol (mg/dL)	52 ± 2	103 ± 5^#	116 ± 6^#	122 ± 16^#	49 ± 4^*⁺^§
Triglycerides (mg/dL)	123 ± 10	129 ± 14	141 ± 25	92 ± 17	59 ± 6^#^*⁺
Heart/body weight ratio (×10^-3)	3.86 ± 0.08	4.86 ± 0.11^#	4.67 ± 0.11^#	4.01 ± 0.06^*⁺	4.18 ± 0.15^*⁺
Segmental sclerosis (% of glomeruli)	0	4.87 ± 0.77^#	4.38 ± 0.98^#	5.30 ± 0.52^#	1.46 ± 0.27^*⁺^§
Glomerular area (μm²)	10,723 ± 380	16,416 ± 316^#	17,238 ± 613	15,085 ± 369^#^*⁺	12,591 ± 382^#^*⁺^§
Blood Vessels (lumen/wall thickness)
Arcuate arteries	0.98 ± 0.07	0.80 ± 0.05	0.94 ± 0.04^*	0.93 ± 0.03	1.03 ± 0.07^*
Interlobular arteries	0.83 ± 0.05	0.50 ± 0.04^#	0.45 ± 0.04	0.40 ± 0.03^#	0.84 ± 0.08^*⁺^§
Arterioles	0.61 ± 0.03	0.35 ± 0.03^#	0.32 ± 0.03	0.35 ± 0.03^#	0.63 ± 0.02^*⁺^§
Tubular casts (% of cortical surface area)	0.25 ± 0.10	13.23 ± 1.27^#	11.36 ± 1.41^#	13.46 ± 0.86^#	6.06 ± 0.47^#^*⁺^§

Values are mean ± SEM. SR, salt-resistant rats; SS, salt-sensitive rats; HSD, high-salt diet (8% NaCl); CO, corn oil (25%); HYD, hydralazine (5 mg/kg/d); FO, fish oil (25%).

P<0.05 vs. SR+HSD,

P<0.05 vs. SS+HSD,

⁺

P<0.05 vs. SS+HSD+CO,

^§

P<0.05 vs. SS+HSD+HYD.