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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Chem Rev. 2010 Mar 10;110(3):1642–1662. doi: 10.1021/cr900228f

Figure 10.

Figure 10

The time-dependent couplings between guanines separated by three different four-base sequence contexts, based on conformations generated through molecular dynamics. It is clear that the average value of coupling can be several orders of magnitude lower than the maximum coupling. For the poorly stacked, flexible ATAT sequence, strong coupling between the guanines is not achieved over the time-scale of the simulation. Reprinted with permission from Reference 211. Copyright American Chemical Society.