Skip to main content
. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Chem Rev. 2010 Mar 10;110(3):1642–1662. doi: 10.1021/cr900228f

Figure 6.

Figure 6

Oxidation and repair of thymine dimer (~1.8 eV) by tethered photoexcited [Rh(phi)2(bpy’)]3+ (2.0 V) is unaffected by the intervening double guanine site (1.2 eV). Oxidation of double guanine sites by [Ru(phen)(bpy’)(dppz)]3+ (1.5 eV) is unaffected by the presence of thymine dimer, which this oxidant lacks sufficient driving force to repair. The latter result implies that guanine radical is not competent to repair thymine dimers, in accordance with the known potentials. Hence either the guanine radical oxidized by [Rh(phi)2(bpy’)]3+ does not relax prior to migration to the thymine dimer, or the guanine radical is not an intermediate in DNA-mediated oxidation of thymine dimer by [Rh(phi)2(bpy’)]3+.