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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Chem Rev. 2010 Mar 10;110(3):1642–1662. doi: 10.1021/cr900228f

Figure 7.

Figure 7

Scale diagram describing the relevant potentials for DNA-mediated CT through DNA self-assembled monolayers on gold. The potentials of the individual nucleotides are not accessible within the window of electrochemistry of DNA monolayers on Au. Nevertheless, facile DNA-mediated electrochemistry is observed for redox probes over DNA bridges. For all probes and sequences of well-matched duplexes, the tunneling through the alkane linker is rate limiting (~30 s−1). Shown, in order from top, are daunomycin, methylene blue, Redmond Red, and a [4Fe-4S] cluster similar to those in the redox-active repair proteins EndoIII and MutY.