Fig. 5.

Representative pictures of DHE (a), gene expression of gp91^phox (b) and p22^phox (c) and complex formation of p22^phox with p47^phox (d) or Rac-1 (e) in renal cortical tissues. Increased renal cortical mRNA expression of gp91^phox and p22^phox in SHR/ND was significantly suppressed by cilnidipine but not by amlodipine. Similarly, increased complex formation of p22^phox with p47^phox or Rac-1 was suppressed by cilnidipine but not by amlodipine. ^*P < 0.05 vs. WKY, ^#P < 0.05 vs. SHR/ND, ^†P < 0.05 vs. SHR/ND + amlodipine. DHE, dihydroethidium; SHR, spontaneously hypertensive rat; WKY, Wistar–Kyoto rats.