Table 1.
WKY (n = 12) | SHR (n = 12) | SHR/ND (n = 12) | SHR/ND + cilnidipine (n = 12) | SHR/ND + amlodipine (n = 11) | |
---|---|---|---|---|---|
BW (g) | 451 ± 4 | 422 ± 6* | 722 ± 13* | 702 ± 10* | 698 ± 16* |
BG (mmol/l) | 5.2 ± 0.2 | 5.4 ± 0.3 | 9.8 ± 1.0* | 9.1 ± 0.9* | 11.5 ± 0.8* |
PTG (mg/dl) | 87 ± 5 | 78 ± 9 | 341 ± 41* | 174 ± 20*,# | 350 ± 101* |
Pcre (mg/dl) | 0.56 ± 0.02 | 0.55 ± 0.02 | 0.55 ± 0.02 | 0.55 ± 0.02 | 0.55 ± 0.02 |
PAngII (fmol/ml) | 14 ± 2 | 15 ± 2 | 9 ± 3* | 6 ± 1* | 15 ± 3 |
TBARS (nmol/mg protein) | 0.21 ± 0.02 | 0.28 ± 0.04 | 0.47 ± 0.03* | 0.27 ± 0.02# | 0.35 ± 0.08 |
Values are mean ± SE. BW, body weight; BG, postprandial blood glucose; Pcre, plasma creatinine; PAngII, plasma AngII; PTG, plasma triglyceride; SHR, spontaneously hypertensive rat; TBARS, thiobarbituric acid-reactive substances; WKY, Wistar–Kyoto rats.
P < 0.05 vs. WKY.
P < 0.05 vs. SHR/ND.