Figure 4.
Alignment of DNA sequences of zebrafish crx showing regions of sequence variability. Alignment of crx sequence data from mok and nie wild-type sibs with published zebrafish genomic and cDNA sequences reveals areas of sequence variability associated with repetitive sequence elements in both non-coding and intronic regions. A: The GA repeat in the 5′ untranslated region of exon 1; B: the CATC tretranucleotide repeat region in intron 2; and C: the GA repetitive element and flanking G/A rich sequence in the 3′ untranslated region in exon 3. Asterisks (*) under sequence indicate variable bases; dashes indicate gaps introduced to optimize alignment. Sequence data from mok and nie were obtained from the present study; additional zebrafish sequences were obtained from the publicly available databases as follows: AF0503443 from crx cDNA sequence NCBI database [4]; zc12909 genomic sequence from Sanger database; and ctg13244 genomic sequence from Ensembl Database.