Table 1.

Time-dependent changes in M-mode echocardiogram of age-matched inducible cardiac specific ClC-3 knock-out mice with doxycycline (on Doxy) in the diet or after withdraw of doxycycline (off doxy) from the diet.

	0 week		1.5 weeks		3 weeks
	On Doxy	Off Doxy	On Doxy	Off Doxy	On Doxy	Off Doxy
	n=8	n=15	n=4	n=12	n=5	n=9
IVSs (mm)1	1.6±0.03	1.6±0.04	1.7±0.01	1.5±0.04*,##	1.6±0.03	1.5±0.04*
LVIDs (mm)	1.0±0.1	1.0±0.1	1.1±0.1	1.5±0.11***	1.2±0.1	1.6±0.1***,#
LVPWs (mm)	1.4±0.1	1.5±0.1	1.2±0.1	1.3±0.04	1.3±0.03	1.3±0.04
IVSd (mm)	0.8±0.02	0.8±0.02	0.8±0.02	0.8±0.02	0.8±0.02	0.8±0.02
LVIDd (mm)	2.7±0.2	2.9±0.1	2.7±0.1	3.3±0.1*,#	2.9±0.1	3.2±0.1*,#
LVPWd (mm)	1.1±0.1	1.1±0.03	1.0±0.04	1.1±0.04	1.0±0.1	1.1±0.1
FS (%)	64.1±1.7	67.1±1.8	59.3±1.9	54.3±1.9***	60.5±1.8	51.6±1.8***,##
LVEF (%)	95.1±0.7	96.0±1.6	93.0±0.9	89.8±1.2**	93.6±0.1	88.2±1.3**,##
Mass (mg/mm2)	80.0±4.3	92.9±3.42	72.1±4.1	102.5±4.4##	87.8±5.3	102.1±3.0#
Body Weight (g)	34.9±2.6	43.1±1.9#	33.2±3.6	41.2±2.1	38.2±1.8	36.3±2.4
Mass/BW Ratio	2.4±0.2	2.2±0.1	2.3±0.2	2.5±0.1*	2.3±0.1	2.9±0.1***,#

¹systolic and diastolic left ventricular (LV) interventricular septum and posterior wall thickness (IVS and LVPW), chamber dimension (LVID), mass (LVM), LVM/body weight (BW) ratio, and contractile function (LV ejection fraction (LVEF) and percent fractional shorting (%FS)).

^*P<0.05,

^**P<0.01,

^***P<0.001 vs off Doxy 0 week;

^#P<0.05,

^##P<0.01,

^###P<0.001 vs on Doxy at the same time point using ANOVA.