Fig. 2 Relative risk of all-cause mortality for early invasive therapy compared with conservative therapy at a mean follow-up of 2 years. The results show a long-term survival benefit from early invasive therapy.

CI = confidence interval; FRISC-II = Fragmin and Fast Revascularization during Instability in Coronary Disease-II; ICTUS = Invasive versus Conservative Treatment in Unstable Coronary Syndromes; ISAR-COOL = Intracoronary Stenting with Antithrombotic Regimen Cooling Off; RITA-3 = Randomized Intervention Trial of Unstable Angina-3; RR = relative risk; TIMI-18 = Thrombolysis In Myocardial Infarction-18; TRUCS = Treatment of Refractory Unstable Angina in Geographically Isolated Areas without Cardiac Surgery; VINO = Value of First Day Coronary Angiography/Angioplasty in Evolving Non–ST-Segment Elevation Myocardial Infarction

Reprinted with permission from: Bavry AA, Kumbhani DJ, Rassi AN, Bhatt DL, Askari AT. Benefit of early invasive therapy in acute coronary syndromes: a meta-analysis of contemporary randomized clinical trials. J Am Coll Cardiol 2006;48(7):1319–25.⁷²