Table 1.
Curcumin neutralizes αS-induced cytotoxicity in SH-SY5Y cells
| Sample | LDH (% control) | SE | p-value | Viability (% control) | SE | p-value |
|---|---|---|---|---|---|---|
| Tris buffer (control) | 100 | 2.4 | NA | 100 | 4.3 | NA |
| αS | 121.5 | 3.5 | 0.005a | 67.9 | 1.9 | 0.004a |
| αS + curcumin | 99.7 | 5.3 | 0.018b | 89.1 | 4.1 | 0.008b |
| Curcumin | 99.3 | 4.9 | 0.936 | 96.8 | 5.6 | 0.501 |
Cytotoxicity was measured using LDH assay and cell viability was determined using resazurin reduction assay. SH-SY5Y cells were incubated with Tris buffer (control), αS, αS+curcumin and curcumin for 48 hr before analysis. The LDH release and cell viability were expressed as a percentage of the untreated samples. Data was reported as mean ± SE, n = 4. acompared with the control; bcompared with αS-treated samples.