Table 3.
Protein Z antigen, protein Z-dependent protease inhibitor (ZPI) antigen and function according to the clinical extent (Fontaine stage) of the peripheral arterial disease
| Protein Z antigen | ZPI antigen | ZPI function | |
|---|---|---|---|
| Controls (n = 190) | 90 (87–94) | 93 (89–97) | 96 (92–100) |
| Stage IIb (n = 74) | 75 (70–81) | 92 (86–98) | 88 (82–94) |
| Stage III (n = 14) | 60 (47–73) | 68 (54–81) | 68 (54–82) |
| Stage IV (n = 7) | 58 (39–77) | 43 (23–62) | 50 (29–70) |
| P for trend | < 0.0001 | < 0.0001 | < 0.0001 |
Data are presented as geometric mean (95% confidence interval). General linear model adjusted for age, gender, smoking habit, hypertension, diabetes, dyslipidemia, and family history of cardiovascular diseases.