Table 3. Epidemiological and cost estimates used in the Economic Benefit Model.
| Parameter Type | Acute or Chronic Disease | Associated Cost-Type | Rate or Proportion | Regional Variation | Hydrocele Avg. Estimate1 | Lymphedema Avg. Estimate1 | Sources, Key Assumptions | ||
| Epidemiological | Acute Disease | Direct and Indirect | % of clinical LF patients with ADL | Global estimate2 | 70% | [45–90%] | 95% | [90–95%] | [33], [35], [39], [40], [41], [42], [43], [44], [45] |
| % of patients with ADL seeking treatment | Global estimate, India excepted3 | 65% | [55–70%] | 65% | [55–70%] | [33], [34], [35], [42] | |||
| # of ADL episodes per patient (w/o MDA) | Global estimate2 | 2 | [0–7] | 4 | [0–7] | [33], [35], [39], [40], [41], [42], [43], [44], [45] | |||
| % of ADL episodes prevented by MDA | Global estimate2 | 50% | [15–88%] | 50% | [15–88%] | [21], [22], [23], varies by MDA round | |||
| Indirect Cost | Avg. duration of ADL episode (days) | Global estimate2 | 4 | [0–9] | 4 | [0–9] | [33], [35], [39], [40], [41], [42], [43], [44], [45] | ||
| % of work hours lost per day due to ADL | Global estimate2 | 75% | [50–93%] | 75% | [50–93%] | [40], [42], [44], [51] | |||
| Chronic Disease | Direct and Indirect | % of Chronic disease patients seeking treatment | Global estimate, India excepted3 | 40% | [20–50%] | 50% | [30–55%] | [34], [36], [37], [38] | |
| % of Chronic disease patients benefiting from MDA | Global estimate2 | 10% | [0–87%] | 15% | [0–69%] | [24], [25], [26], [27], [28], [31], [55], varies by MDA round | |||
| Indirect Cost | % of work hours lost per day due to chronic disease | Global estimate2 | 15% | [13–17%] | 20% | [15–22%] | [36], [37], [40] | ||
| Cost | Acute Disease | Direct Cost | Avg. treatment cost per episode | Country-specific estimate4 | $1.5 | [$0.25–$5.20] | $1.5 | [$0.25–$5.20] | [9], [10], [33], [34], [35], [36], [37] |
| Chronic Disease | Direct Cost | Avg. treatment cost per year | Country-specific estimate4 | $2.9 | [$0.55–$10.05] | $4.3 | [$0.85–$15.00] | [9], [10], [33], [34], [35], [36], [37] | |
| Acute and Chronic Disease | Indirect Cost | Avg. wage per day | Country-specific estimate4 | $1.05 | [$0.30–$5.60] | $1.05 | [$0.30–$5.60] | [11], [12], [13], [14] | |
| Chronic Disease | Indirect Cost | Work days per year | Global estimate2 | 300 | [300–365] | 300 | [300–365] | Assuming 6 workdays/week | |
1
Weighted average over all GPELF countries.
2
Global estimate indicates a standard rate or proportion was utilized for each GPELF country. This is primarily due to a lack of supporting country-specific data.
3
Indicates a standard rate or proportion was utilized for each GPELF country with the exception of India where more primary data was available and suggested estimates differ from other GPELF regions.
4
Estimates are country-specific and gathered from public online international database sources.