Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Endocrinol Metab Clin North Am. 2010 Jun;39(2):255–269. doi: 10.1016/j.ecl.2010.02.007

Figure 2.

Figure 2

Schematic model of coregulatory complexes that are involved in mediating the actions of 1,25(OH)2D3 and the VDR. The general transcriptional apparatus is shown at the TSS and the VDR/RXR heterodimer is shown bound to its regulatory vitamin D response element or VDRE. Three regulatory complexes are shown that interact with the VDR: an ATPase-containing, chromatin remodeling complex termed SWI/SNF, a histone acetylation complex containing histone acetyltransferases (HAT) and Mediator complex. The latter facilitates the activation of RNA pol II through its C-terminal domain (CTD). Nucleosomes as well as individual proteins that comprise the individual coregulatory complexes are indicated.