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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Genes Brain Behav. 2008 Mar 21;7(6):629–638. doi: 10.1111/j.1601-183X.2008.00399.x

Figure 3.

Figure 3

Scn8a+/− mice extinguish contextually-conditioned fear as well as WT mice. (A) Both Scn8a+/− mice (N = 31) and WT mice (N = 24) exhibited increases in freezing as training progressed with Scn8a+/− mice consistently freezing more than WT mice in the intervals following and between shocks. (B) Scn8a+/− mice (N = 21) exhibited more freezing than WT mice (N = 16) across a one-hour exposure to the conditioning chambers, but there was no genotype-training interaction. (C) Twenty-four hours after extinction training, mice were re-exposed to the conditioning chambers. Scn8a+/− mice froze significantly more than WT mice and retention control mice froze more than mice in the extinction group, but there was no interaction between genotype or group. All data are presented as mean ± S.E.M. (*) p < 0.05 two-way ANOVA; training group factor.