Table 2.

Increased Marker Expression in STICs Correlated with Ki-67 Proliferation Index.

Ki-67 Index	No. of Cases	p53	p16	Rsf-1	Cyclin E	FASN
<10%	8	5/8 (63%)	3/7(43%)	3/7 (43%)	5/8 (63%)	5/8 (63%)
10-49%	14	13/14 (93%)	6/14 (43%)	10/13 (77%)	6/13 (46%)	7/14 (50%)
≥ 50%	15	14/14 (100%)	9/12 (75%)	9/15 (60%)	13/14 (93%)	11/15 (73%)
total	37	32/36 (89%)	18/33 (55%)	22/35 (63%)	24/35 (77%)	23/37 (62%)

For p53 a case was considered positive if the intensity score was 0 or ≥50% (intense nuclear) since both of these patterns are associated with TP53 mutations. Increased expression for p16 was defined as ≥ 50% of positive cells, for cyclin E ≥ 10% of positive cells, for Rsf-1 ≥ 1 (final score) and for FASN ≥ 1 (final score). The final score for Rsf-1 and FASN was determined by subtracting the intensity of the stain in normal adjacent tubal epithelium from the initial intensity score in the STIC.