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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Pain. 2009 Dec 16;11(6):588–599. doi: 10.1016/j.jpain.2009.09.018

Figure 1. Heat hypersensitivity after L4 SNL is mediated by TRPV1.

Figure 1

Paw withdrawal latencies to heat in mice after L4 SNL. A. Mice developed heat hypersensitivity in the ipsilateral paw 4 days after SNL; the hypersensitivity persisted through 10 days. The ipsilateral (SNL side) paw was compared to the contralateral paw. One-way ANOVA main effect for all time points, both sides was p<0.05. Right and left paws were compared for individual time points using paired t-tests (**p<0.01; *p<0.05; n ≥ 4 for each time point). B. Vehicle treatment (i.p.) 30 min prior to the behavioral test on each day did not alleviate the SNL-induced heat hypersensitivity. Two-way repeated measures ANOVA main effect for all time points, both sides was p< 0.05. Right and left paws were compared for individual time points using paired t-tests (**p<0.01; *p<0.05; n=5). C. Treatment with A-425619 (200 μmol/kg, i.p.) 30 min prior to the behavioral test on each day completely blocked the heat hypersensitivity in the ipsilateral paw. Two-way repeated measures ANOVA (p>0.1; n=5). D. In addition, the effect of A-425619 versus vehicle was compared by calculating the difference between the ipsilateral and contralateral paw withdrawal responses in the A-425619-treated group to that in the vehicle-treated group (two-way repeated measures ANOVA main effect p < 0.05; a t-test compared the difference at each time point between A-425619- and vehicle-treated mice (**p<0.01; * p<0.05).