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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Pain. 2009 Dec 16;11(6):588–599. doi: 10.1016/j.jpain.2009.09.018

Figure 2. Responsiveness of naive small-diameter neurons to heat and capsaicin.

Figure 2

A. Example of a small-diameter neuron responding to heat (22–50 °C in 3 sec) with a clear threshold of 46 °C. Repeated heat responses showed little sensitization or desensitization. B. Example of the non-specific background current in a heat-insensitive neuron.

CD. Percentage of small-diameter (≤ 26 μm) neurons that responded to heat (C) or 1 μM capsaicin (D). Many IB4 negative neurons responded to both heat and capsaicin, whereas few IB4 positive neurons responded to either stimulus. E. Percentage of medium-large neurons (>26 μm in diameter) that responded to heat or capsaicin (1 μM).