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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Pain. 2009 Dec 16;11(6):588–599. doi: 10.1016/j.jpain.2009.09.018

Figure 3. TRPV1 inhibition by A-425619 blocks all heat responses in DRG neurons.

Figure 3

A. Example of a heat-evoked current in a small-diameter neuron that is completely blocked by A-425619 (1 μM) and recovers by 2 min after washout. B. Quantification of the magnitude of heat responses in naive small neurons before, during and after inhibition with A-425619 (n=6). After the first heat test, neurons were superfused with A-425619 (1 μM) for 2 min and then tested with heat in the presence of the antagonist. Note that the heat response shows almost complete recovery by 2 min after washout of A-425619. Error bars represent SEM.