TABLE II. Associations Between Enrollment SB-eNO And Changes In Lung Function.
Δ FEV0.5 z-scores | Δ FEF25-75 z-score | Δ FEF75 z-score | ||||
---|---|---|---|---|---|---|
ß Coefficient | P value | ß Coefficient | P value | ß Coefficient | P value | |
Enrollment SB-eNO (10ppb increments) |
-0.40 | 0.01 | -0.40 | 0.01 | -0.42 | 0.003 |
Eczema (yes/no; physician-diagnosed and steroid treated)) |
-0.34 | 0.3 | -0.73 | 0.1 | -0.3 | 0.4 |
Sustained ICS use during follow-up (yes/no) |
0.84 | 0.1 | 1.3 | 0.03 | 1.1 | 0.04 |
Gender | -0.08 | 0.8 | -0.11 | 0.8 | 0.07 | 0.9 |
Age at enrollment (1 month increments) |
-0.03 | 0.4 | -0.06 | 0.2 | -0.04 | 1.0 |
FH Asthma (yes/no) |
0.24 | 0.5 | 0.32 | 0.5 | -0.04 | 0.9 |
Tobacco smoke exposure (yes/no) |
-0.56 | 0.2 | -0.62 | 0.2 | -0.47 | 0.3 |
Definition of Abbreviations: SB-eNO = single-breath exhaled nitric oxide; ICS = inhaled corticosteroids; FH = family history. N=32 subjects. ß Coefficient represents change in lung function z-score associated with each variable or increment of a variable (e.g 10ppb increment of SB-eNO). Bold type denotes a statistically significant association.