TABLE III. Sensitivity, Specificity, PPV, and NPV of Enrollment SB-eNO, FEV0.5, FEF25-75 and Bronchodilator Responsiveness for Wheezing Exacerbations Treated With Systemic Corticosteroids During Follow-Up.
| Cutoff | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
| SB-eNO | >29ppb | 88% | 82% | 70% | 92% |
| Enrollment FEV0.5 | z-score < -0.53 | 31% | 59% | 29% | 61% |
| Enrollment FEF25-75 | z-score < -1.0 | 31% | 58% | 29% | 60% |
| BR | ≥ 12% improvement FEV0.5, or ≥ 25% improvement FEF25-75 | 33% | 78% | 44% | 69% |
| SB-eNO and FEV0.5 | >29ppb; z-score < -0.53 | 25% | 89% | 57% | 68% |
| SB-eNO and FEF25-75 | >29ppb; z-score < -1.0 | 38% | 93% | 75% | 73% |
| SB-eNO > 29ppb and BR | >29ppb; BR | 33% | 91% | 67% | 72% |
Definition of Abbreviations: PPV = positive predictive value; NPV = negative predictive value; SB-eNO = single-breath exhaled nitric oxide; BR = bronchodilator responsive