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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 May 11;125(6):1228–1234.e13. doi: 10.1016/j.jaci.2010.03.023

TABLE III. Sensitivity, Specificity, PPV, and NPV of Enrollment SB-eNO, FEV0.5, FEF25-75 and Bronchodilator Responsiveness for Wheezing Exacerbations Treated With Systemic Corticosteroids During Follow-Up.

Cutoff Sensitivity Specificity PPV NPV
SB-eNO >29ppb 88% 82% 70% 92%
Enrollment FEV0.5 z-score < -0.53 31% 59% 29% 61%
Enrollment FEF25-75 z-score < -1.0 31% 58% 29% 60%
BR ≥ 12% improvement FEV0.5, or ≥ 25% improvement FEF25-75 33% 78% 44% 69%
SB-eNO and FEV0.5 >29ppb; z-score < -0.53 25% 89% 57% 68%
SB-eNO and FEF25-75 >29ppb; z-score < -1.0 38% 93% 75% 73%
SB-eNO > 29ppb and BR >29ppb; BR 33% 91% 67% 72%

Definition of Abbreviations: PPV = positive predictive value; NPV = negative predictive value; SB-eNO = single-breath exhaled nitric oxide; BR = bronchodilator responsive