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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Pain. 2009 Dec 16;11(6):535–544. doi: 10.1016/j.jpain.2009.09.010

Table 2. Series 2 Raw Paw Withdrawl Latencies.

Paw withdrawal latencies (in s) to a thermal nociceptive stimulus after PnO microinjection of saline (A), hypocretin-1 (B), hypocretin-1 + SB-334867 (C), and SB-334867 (D). Data from each rat are reported for each post-injection time point. The overall latency for each animal is in the far right column; the overall mean, standard deviation (SD), standard error of the mean (SEM), and coefficient of variation (%CV) for each time point are located at the bottom of the table, and the grand means for the experimental condition are located in the bottom four rows of the far right column.

A. Saline Time Post-Injection (min)
Rat ID BL 10 20 30 60 90 120 Mean
R1 7.55 7.91 12.54 9.46 8.51 7.88 9.24 9.25
R2 7.46 6.51 3.88 5.16 6.44 6.71 6.31 5.83
R3 6.27 8.89 4.76 5.46 5.09 5.46 6.42 6.01
R4 5.01 5.53 6.36 5.34 4.69 4.92 5.19 5.34
R5 6.17 5.11 6.08 6.21 5.55 5.96 5.06 5.66
R6 8.95 8.51 7.42 9.57 9.82 5.73 8.21 8.21
R7 5.81 5.09 5.88 5.01 5.96 5.15 5.53 5.44
R8 7.29 7.89 6.61 6.19 5.86 6.30 5.83 6.45
R9 6.40 6.77 6.24 6.16 6.46 6.46 5.24 6.22
R10 6.10 6.13 6.29 6.31 6.70 7.12 5.20 6.29
R11 5.73 4.71 5.21 5.25 5.71 5.28 4.77 5.15
Mean 6.61 6.64 6.48 6.37 6.44 6.09 6.09 6.35
SD 1.10 1.47 2.23 1.62 1.50 0.91 1.42 1.27
SEM 0.33 0.44 0.67 0.49 0.45 0.27 0.43 0.38
%CV 5.02 6.69 10.37 7.68 7.03 4.51 7.01 6.02
B. Hypocretin-1
Rat ID BL 10 20 30 60 90 120 Mean
R1 7.54 8.31 8.71 7.22 9.19 6.96 8.84 8.21
R2 6.42 7.59 6.39 4.80 6.93 6,76 5.67 6.36
R3 5.36 6.06 4.65 6.17 6.31 5.78 6.81 5.96
R4 5.47 4.30 5.34 3.98 4.59 5.42 4.73 4.73
R5 6.41 6.89 5.85 7.39 8.59 7.33 13.00 8.18
R6 5.89 9.67 7.64 7.71 7.74 5.23 10.66 8.11
R7 7.00 8.51 7.29 7.28 7.76 5.46 4.49 6.80
R8 6.87 8.66 7.08 7.49 6.73 10.67 6.97 7.93
R9 6.55 7.63 6.71 6.61 8.06 7.59 6.48 7.18
R10 5.52 5.47 6.90 8.57 6.35 6.07 6.40 6.63
R11 6.05 5.48 5.26 5.55 5.58 6.00 5.68 5.59
Mean 6.28 7.14 6.53 6.62 7.08 6.66 7.25 6.88
SD 0.70 1.65 1.19 1.37 1.35 1.55 2.60 1.17
SEM 0.21 0.50 0.36 0.41 0.41 0.47 0.78 0.35
%CV 3.35 6.97 5.48 6.24 5.76 7.02 10.82 5.11
C. Hypocretin-1 + SB 334867
Rat ID BL 10 20 30 60 90 120 Mean
R1 7.08 10.09 9.23 7.27 7.33 7.51 7.96 8.23
R2 7.00 8.01 6.94 6.57 6.19 7,29 7.38 7.06
R4 5.16 4.41 4.41 4.48 3.76 4.86 5.17 4.52
R7 6.64 5.58 5.01 4.56 5.88 5.51 6.77 5.55
R8 7.21 5.55 6.24 5.91 7.60 7.89 5.50 6.45
R9 6.31 6.84 6.67 5.83 5.22 6.08 5.92 6.09
R10 6.33 6.62 6.22 5.95 5.09 6.43 5.94 6.04
R11 5.82 5.58 6.75 5.65 5.32 6.53 4.93 5.79
Mean 6.44 6.58 6.43 5.78 5.80 6.51 6.20 6.22
SD 0.70 1.78 1.43 0.93 1.25 1.03 1.08 1.10
SEM 0.21 0.54 0.43 0.28 0.38 0.31 0.32 0.33
%CV 3.28 8.16 6.72 4.88 6.50 4.77 5.24 5.31
D. SB-334867
Rat ID BL 10 20 30 60 90 120 Mean
R2 7.43 7.24 6.24 6.67 5.36 6.43 6.72 6.45
R3 5.52 5.61 4.94 4.69 5.38 4.55 5.79 5.16
R4 4.05 4.43 3.58 4.85 5.10 4.71 4.61 4.55
R5 5.87 6.36 5.56 7.89 5.25 4.86 5.26 5.86
R6 5.65 4.64 6.11 5.69 4.75 5.26 5.73 5.36
R7 6.46 6.68 5.65 5.20 4.90 5.97 5.46 5.64
R9 6.70 6.62 6.39 6.91 5.31 6.16 6.11 6.25
R10 6.71 5.62 5.36 5.81 6.34 6.12 5.93 5.86
R11 6.37 6.94 5.24 6.18 5.56 5.34 5.81 5.84
Mean 6.08 6.02 5.45 5.99 5.33 5.49 5.71 5.66
SD 0.97 1.00 0.85 1.04 0.45 0.70 0.58 0.58
SEM 0.32 0.33 0.28 0.35 0.15 0.23 0.19 0.19
%CV 5.31 5.54 5.21 5.80 2.85 4.26 3.40 3.39