Figure 3.

The impact of HJURP expression and Ki67 proliferation indices on the disease-free and overall survival. Figure 3 shows Kaplan-Meier survival curves for breast cancer patients according to tumor expression of HJURP. The patients from each cohort were divided into a group with high (top one-third), moderate (middle one-third) and low (bottom one-third) level of HJURP expression. HJURP expression is measured log₂ (probe intensities) as in the microarray. The same criteria were used for Ki67 proliferation indices. HJURP mRNA expression was a significant prognostic factor for disease-free and overall survival, whereas Ki67 proliferation indices were not significantly associated with prognosis. (a) Kaplan-Meier survival curves for disease-free and overall survival are presented, while (b) shows the Kaplan-Meier survival curves for disease-free and overall survival based on Ki67 proliferation indices. The P-values shown were obtained from a long-rank test.