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The type and frequency of mutations in phosphatidylinositol 3-kinase (PI3K) pathway components in breast cancer
| PI3K component | Type of mutation | Incidence |
|---|---|---|
| P110a (PIK3CA) | Mutation | 27% |
| P110α (PIK3CA) | Amplification | 8.7% |
| P110β (PIK3CB) | Amplification | 5% |
| PDPK1 | Amplification and overexpression | 20% |
| AKT1 | Mutation (E17K) | 3.7% |
| AKT2 | Amplification | 3% |
| PTEN | Loss of heterozygosity | 24.9% |
| PTEN | Mutation | 6% |
