Fig. 7.
ADMA potentiates the decrease in transendothelial electrical resistance (TER) associated with VEGF exposure in human lung microvascualr endothelial cells. Confluent were exposed or not to ADMA (5 μM, 1 h). Cells were then exposed or not to VEGF (100 ng) and changes in TER across the endothelial cell monolayer were measured by ECIS. Although ADMA alone does not induce a change in TER there is a potentiation in the decrease in TER associated with VEGF exposure. Values are mean ± SE, N=5. *P<0.05 vs. untreated, †P<0.05 vs. VEGF alone.