Table 3.

Longitudinal change in regional cerebral volumes: a summary of the latent difference models.

ROI	Mean				Variance
	T1	Δ12	Δ23	Δ12=Δ23	T1	Δ12	Δ23	Δ12=Δ23
Cortical regions and subcortical nuclei
HC	3.06*	−0.04*	−0.16*	*	0.11*	0.00	0.02*	*
EC	1.28*	−0.02*	−0.03*	ns	0.02*	0.00	0.01*	*
LPFC	8.98*	−0.02	0.15	ns	0.14*	0.12*	0.15*	ns
OFC	4.32*	−0.09*	−0.10*	ns	0.26*	0.01	0.02	ns
VC	2.52*	−0.02	0.03	ns	0.15*	0.00	0.01	ns
In	3.95*	−0.03*	−0.01	ns	0.16*	0.00	0.08*	*
Cd	3.72*	−0.02	−0.12*	*	0.20*	0.00	0.02*	*
Pt	3.90*	−0.02	−0.09	ns	0.13*	0.00	0.06*	*
CbH	57.50*	−0.58*	−1.44*	ns	39.01*	0.86*	3.61*	*
White matter
PFw	20.38*	−0.07	−1.14*	*	7.34*	0.46*	0.75*	ns
CC	3.48*	0.02	−0.10*	*	0.21*	0.03*	0.06*	*
Pons	0.91*	−0.01	0.02	ns	0.01*	0.003*	0.01*	*

Note. All measures are in cm³, adjusted for intracranial size and averaged across the hemispheres (except for the midline structures, CC and pons). HC – hippocampus, EC – entorhinal cortex, LPFC – lateral prefrontal cortex, OFC – orbital–frontal cortex, VC – primary visual (pericalcarine) cortex, In – insula, Cd – caudate nucleus, Pt – putamen, CbH – cerebellar hemispheres, PFw – prefrontal white, CC – corpus callosum. T1 – at baseline, Δ12 – change between the baseline and the first follow-up, Δ23 – change between the first and the second follow-ups. Δ12=Δ23 refers to the significance of the tests of equality of mean change and variance change between the two adjacent follow-ups.

^*p<0.05.