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. 2010 Jan 28;2(2):372–394. doi: 10.3390/v2020372

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — ATP-mediated excision of AZTMP and the use of Ap₄AZT as substrate for AZTMP incorporation. (A) ATP attacks the phosphodiester bond removing the drug-MP from the primer terminus, forming a dinucleoside polyphosphate and an unblocked primer [32]. (B) Ap₄AZT is recognized as an analog of AZTTP leading to incorporation of AZTMP and release of ATP [34,35]. The template and primer are shown in blue and green, respectively; AZT is in red.