Figure 2.
Severe leukocytosis (dots) was observed in SLAd animals with myeloid leukemia (2a) (p<0.001). Normal leukocyte range is shown in left box and normal hematocrit in right box (Fig 2a). All leukemic animals exhibited moderate to severe anemia (p=0.034). Only two of the animals presenting with CML, 16228 and 16454, were tested for serum LDH levels prior to the time of autopsy (2b) (p=0.042). Both had a marked increase in LDH. Immortalized tumor cells derived from animal 17436 had an increased LDH production when compared to fresh or PHA blasted PBMC for 24 hours (2c).” Note: the normal ranges (in parenthesis) for all values have been normalized from hundred of animals. We show several healthy controls in LDH graph as a comparison to the affected animals.