Table 1.

Normal, hypertrophic, and keloid scars compared.

Normal	Hypertrophic	Keloid
Confined to edges of original wound	Confined to edges of original wound	Extends beyond edges of wound
Gradual fading and atrophy after maturation	Regresses after initial peak (although often over several years)	Progressive
No treatment required	First-line treatment: silicone patches or gels	First-line treatment: intralesional steroid injection
Best in the elderly	Worst in the young	More common in darker skin
Normal response to TGF-β1	Abnormal response to TGF-β1	Failure of apoptosis