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. Author manuscript; available in PMC: 2011 Apr 19.
Published in final edited form as: Chem Res Toxicol. 2010 Apr 19;23(4):778–787. doi: 10.1021/tx900415k

Figure 7.

Figure 7

Predicted NO concentrations in an inflamed colonic crypt. Concentrations at the crypt center are plotted as a function of height above the base. The calculations assumed that kc = 1.3 s−1 for macrophages and 4.1 s−1 for epithelial cells, based on the BMDM and HCT116 data in Table 2. The rate of NO synthesis used for macrophages was 2.3 pmol s−1 (106 cells)−1 (Table 2); using the cell volume (v) in Table 1, this corresponds to a volumetric rate of 2.4 µM/s. Results are shown for three assumed rates of NO synthesis by epithelial cells: 0, 1.2, and 4.2 µM/s. The latter values correspond to the HCT116 data for capsaicin-resveratrol in Table 2 and H. cinaedi in Table 3, respectively, again using v from Table 1. All other parameter values were as given in Chin et al (2008).