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. Author manuscript; available in PMC: 2010 Jun 2.
Published in final edited form as: Antivir Ther. 2009;14(8):1113–1124. doi: 10.3851/IMP1463

Figure 3. Effect of microbicides on SLPI and defensin gene expression.

Figure 3

After (A) three or (B) seven daily applications of each formulated microbicide, gene expression of β-defensin (BD)1, BD2 and secretory leukocyte protease inhibitor (SLPI) were measured from vaginal tissue by quantitative real-time PCR. Results represent the β-actin normalized values compared with untreated mice (n= at least five mice/group in at least two independent experiments) and are presented as log10 change in gene expression (mean ± SE). aP<0.05. There was no change in gene expression observed for BD1 or BD2 in response to hydroxyethylcellulose (HEC) or tenofovir. N-9, nonoxynol-9.